INCISIVE Implementation Guide
0.1.1 - draft
INCISIVE Implementation Guide
0.1.1 - draft
INCISIVE Implementation Guide - Local Development build (v0.1.1) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions
Bundle Prostate-Cancer-Message-Bundle-Example of type transaction
Entry 1
Request:
POST MessageHeader
Resource MessageHeader:
Generated Narrative: MessageHeader
Resource MessageHeader "prostatemessageheader"
event: Malignant tumor of prostate (disorder) (Details: http://snomed.org code 399068003 = '399068003', stated as 'Malignant tumor of prostate (disorder)')
Destinations
Name Endpoint example https://exemple.com/services?wsdl sender: See above (Organization/prostateorganization01)
Sources
Name Contact Endpoint example example@example.en https://example.en/origin
Entry 2
Request:
POST Organization
Resource Organization:
Generated Narrative: Organization
Resource Organization "prostateorganization01"
Profile: Organization for Breast, Colorectal, Lung and Prostate cancer
identifier: AUTH/?ngen-9?
name: Aristotle university of Thessaloniki
Entry 3
Request:
POST Medication
Resource Medication:
Generated Narrative: Medication
Resource Medication "prostatemedication01"
code: Medication therapy (snomed.org#373873005 "Pharmaceutical / biologic product (product)")
status: ACTIVE
Entry 4
Request:
POST Patient
Resource Patient:
null, DoB: ( Pseudo-anonimized Identifier: 004-000001)
Entry 5
Request:
POST Condition
Resource Condition:
Generated Narrative: Condition
Resource Condition "prostatecondition01"
Profile: Condition for Breast, Colorectal, Lung and Prostate cancer
code: MG30.10 (SNOMED CT#417662000 "History of clinical finding in subject (situation)")
subject: See above (Patient/prostatepatient01)
evidence
Entry 6
Request:
POST Condition
Resource Condition:
Generated Narrative: Condition
Resource Condition "prostatecondition02"
Profile: Condition for Breast, Colorectal, Lung and Prostate cancer
code: Clinical finding (finding) (SNOMED CT#404684003)
subject: See above (Patient/prostatepatient01)
note: Dysuria
Entry 7
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation01"
Profile: Observation for Prostate cancer
status: FINAL
code: Malignant tumor of prostate (disorder) (snomed.org#399068003)
subject: See above (Patient/prostatepatient01)
component
code: Family history of prostate cancer (situation) (snomed.org#414205003)
value: true
component
code: |Family history of cancer (situation)|:|Subject relationship context (attribute)|=|Father (person)| (snomed.org#275937001:408732007=66839005)
value: true
component
code: |Family history of cancer (situation)|:|Subject relationship context (attribute)|=|Mother (person)| (snomed.org#275937001:408732007=72705000)
value: true
Entry 8
Request:
POST DiagnosticReport
Resource DiagnosticReport:
Malignant tumor of prostate (disorder)
Subject Not done yet Report Details
Code Value Malignant tumor of prostate (disorder)
Entry 9
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation02"
Profile: Observation for Prostate cancer
status: FINAL
code: Malignant tumor of prostate (disorder) (snomed.org#399068003)
subject: See above (Patient/prostatepatient01)
bodySite: pZp apex (Localization_of_PIRADS_Prostate#3)
component
code: CT.dcm-path (snomed.org#77477000 "Computed tomography (procedure)")
value: true
component
code: Annotated CT.dcm-path (snomed.org#118247008:418775008=77477000 "|Radiologic finding (finding)|:|Finding method (attribute)|=|Computed tomography (procedure)|")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: PET/CT.dcm-path (snomed.org#82918005 "Positron emission tomography (procedure)")
value: true
component
code: Annotated PET/CT.dcm-path (snomed.org#118247008:418775008=77477000 "|Radiologic finding (finding)|:|Finding method (attribute)|=|Computed tomography (procedure)|")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: MRI.dcm-path (snomed.org#113091000 "Magnetic resonance imaging (procedure)")
value: true
component
code: Annotated MRI.dcm-path (snomed.org#365853002:418775008=113091000 "|Imaging finding (finding)|:|Finding method (attribute)|=|Magnetic resonance imaging (procedure)|")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: |Magnetic resonance imaging (procedure)|:|Property (attribute)|=|Type (property) (qualifier value)| (snomed.org#113091000:370130000=410656007)
value: Prior biopsy (MRI_type_baseline_Prostate#0)
component
code: Bone Scintigraphy Scan.dcm-path (snomed.org#228084000 "Whole body bone imaging (procedure)")
value: true
component
code: Annotated Bone Scintigraphy Scan.dcm-path (snomed.org#118247008:418775008=228084000 "|Radiologic finding (finding)|:|Finding method (attribute)|=|Whole body bone imaging (procedure)|")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: Histopathology Image.dcm-path (snomed.org#252416005 "Histopathology test (procedure)")
value: true
component
code: Annotated Histopathology Image.dcm-path (snomed.org#250537006 "Histopathology finding (finding)")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: Xray.dcm-path (snomed.org#363680008 "Radiographic imaging procedure (procedure)")
value: true
component
code: Annotated Xray.dcm-path (snomed.org#118247008:418775008=168537006 "|Radiologic finding (finding)|:|Finding method (attribute)|=|Plain radiography (procedure)|")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: Prostate Adenoma Volume by derived from height, width and length (US) (LOINC#15326-2)
value: 2 cubic millimetre (Details: UCUM code mm^3 = 'mm^3')
component
code: Anatomic location of neoplasm (observable entity) (snomed.org#371480007)
value: Right (Side_of_tumor_Prostate#0)
component
code: Tumor staging (tumor staging) (snomed.org#254292007)
value: PIRADS 1 (Maximum_PIRADS_Prostate#1)
component
code: Extraprostatic extension of tumor present (finding) (snomed.org#372306004)
value: true
component
code: Seminal vesicle invasion by tumor present (finding) (snomed.org#372294007)
value: true
component
code: Prostate specific Ag [Mass/volume] in Serum or Plasma (LOINC#2857-1)
value: 4.48 nanogram per millliiter (Details: UCUM code ng/mL = 'ng/mL')
component
code: cT category (observable entity) (snomed.org#399504009)
value: cT1 (CT_Baseline_Prostate#1)
component
code: cN category (observable entity) (snomed.org#399534004)
value: N1 (CN_Baseline_Prostate#1)
component
code: cM category (observable entity) (snomed.org#399387003)
value: M1 (CM_Baseline_Prostate#1)
Entry 10
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation03"
Profile: Observation for Prostate cancer
status: FINAL
code: Malignant tumor of prostate (disorder) (snomed.org#399068003)
subject: See above (Patient/prostatepatient01)
value: 2
Components
Code Value[x] Prostate specific Ag [Mass/volume] in Serum or Plasma (LOINC#2857-1) 4.26 nanogram per millliiter (Details: UCUM code ng/mL = 'ng/mL')
Entry 11
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation04"
Profile: Observation for Prostate cancer
status: FINAL
code: Malignant tumor of prostate (disorder) (snomed.org#399068003)
subject: See above (Patient/prostatepatient01)
value: 3
Components
Code Value[x] Prostate specific Ag [Mass/volume] in Serum or Plasma (LOINC#2857-1) 3.5 nanogram per millliiter (Details: UCUM code ng/mL = 'ng/mL')
Entry 12
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation05"
Profile: Observation for Prostate cancer
status: FINAL
code: Malignant tumor of prostate (disorder) (snomed.org#399068003)
subject: See above (Patient/prostatepatient01)
value: 4
Components
Code Value[x] Prostate specific Ag [Mass/volume] in Serum or Plasma (LOINC#2857-1) 4.1 nanogram per millliiter (Details: UCUM code ng/mL = 'ng/mL')
Entry 13
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation06"
Profile: Observation for Prostate cancer
status: FINAL
code: Malignant tumor of prostate (disorder) (snomed.org#399068003)
subject: See above (Patient/prostatepatient01)
value: 5
Components
Code Value[x] Prostate specific Ag [Mass/volume] in Serum or Plasma (LOINC#2857-1) 2.7 nanogram per millliiter (Details: UCUM code ng/mL = 'ng/mL')
Entry 14
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation07"
Profile: Observation for Prostate cancer
status: FINAL
code: Malignant tumor of prostate (disorder) (snomed.org#399068003)
subject: See above (Patient/prostatepatient01)
value: 6
Components
Code Value[x] Prostate specific Ag [Mass/volume] in Serum or Plasma (LOINC#2857-1) 5.8 nanogram per millliiter (Details: UCUM code ng/mL = 'ng/mL')
Entry 15
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation08"
Profile: Observation for Prostate cancer
status: FINAL
category: Between 1st and 2nd dose of CT (), Label timepoints ()
code: After 1st Treatment (Label_Timepoints#1)
subject: See above (Patient/prostatepatient01)
value: 2
component
code: |Malignant tumor of prostate (disorder)|:|Clinical course (attribute)|=|Relapsing course (qualifier value)| (snomed.org#399068003:263502005=255318003)
value: true
component
code: Date of biochemical recurrence - Months from diagnosis (SNOMED CT#396152005:726633004=118226009 "|Raised prostate specific antigen (finding)|:|Temporally related to (attribute)|=|Temporal finding (finding)|")
value: 2
component
code: Free period of BR (SNOMED CT#396152005:726633004=86631001 "|Raised prostate specific antigen (finding)|:|Temporally related to (attribute)|=|Absence of signs (finding)|")
value: 4
component
code: MRI.dcm-path (snomed.org#113091000 "Magnetic resonance imaging (procedure)")
value: true
component
code: Annotated MRI.dcm-path (snomed.org#365853002:418775008=113091000 "|Imaging finding (finding)|:|Finding method (attribute)|=|Magnetic resonance imaging (procedure)|")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: CT.dcm-path (snomed.org#77477000 "Computed tomography (procedure)")
value: true
component
code: Annotated CT.dcm-path (snomed.org#118247008:418775008=77477000 "|Radiologic finding (finding)|:|Finding method (attribute)|=|Computed tomography (procedure)|")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: Bone Scintigraphy Scan.dcm-path (snomed.org#228084000 "Whole body bone imaging (procedure)")
value: true
component
code: Annotated Bone Scintigraphy Scan.dcm-path (snomed.org#118247008:418775008=228084000 "|Radiologic finding (finding)|:|Finding method (attribute)|=|Whole body bone imaging (procedure)|")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: PET/CT.dcm-path (snomed.org#764685004 "Positron emission tomography of whole body using choline C-11 (procedure)")
value: true
component
code: Annotated PET/CT.dcm-path (snomed.org#118247008:418775008=764685004 "|Radiologic finding (finding)|:|Finding method (attribute)|=|Positron emission tomography of whole body using choline C-11 (procedure)|")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: Histopathology Image.dcm-path (snomed.org#252416005 "Histopathology test (procedure)")
value: true
component
code: Annotated Histopathology Image.dcm-path (snomed.org#250537006 "Histopathology finding (finding)")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: Xray.dcm-path (snomed.org#363680008 "Radiographic imaging procedure (procedure)")
value: true
component
code: Annotated Xray.dcm-path (snomed.org#118247008:418775008=168537006 "|Radiologic finding (finding)|:|Finding method (attribute)|=|Plain radiography (procedure)|")
value: Positive annotation (Annotated_Dicom_files_Prostate#1)
component
code: Radiation oncology AND/OR radiotherapy (procedure) (snomed.org#108290001)
value: true
component
code: Prostate specific Ag [Mass/volume] in Serum or Plasma (LOINC#2857-1)
value: 4.26 nanogram per millliiter (Details: UCUM code ng/mL = 'ng/mL')
component
code: Androgen deprivation therapy (procedure) (snomed.org#707266006)
value: true
component
code: pM category (observable entity) (snomed.org#371497001)
value: true
Entry 16
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation09"
Profile: Observation for Prostate cancer
status: FINAL
category: Between 1st and 2nd dose of CT (), Label treatment ()
code: After 1st Treatment-1st FollowUp (Label_Treatment#1)
subject: See above (Patient/prostatepatient01)
component
code: Dissection of lymph node (procedure) (snomed.org#11971000224104)
value: true
component
code: Response to treatment (situation) (snomed.org#182985004)
value: CR (Response_to_treatment_Prostate#1)
Entry 17
Request:
POST Procedure
Resource Procedure:
Generated Narrative: Procedure
Resource Procedure "prostateprocedure01"
Profile: Procedure for Prostate cancer
status: COMPLETED
category: EBRT = External Beam Radiotherapy (Type_of_Therapy_Prostate#0)
code: Active surveillance (Treatment_Prostate#1)
Entry 18
Request:
POST Procedure
Resource Procedure:
Generated Narrative: Procedure
Resource Procedure "prostateprocedure02"
Profile: Procedure for Prostate cancer
status: COMPLETED
statusReason: Biopsy label (Label_Biopsy#2 "After 1st Treatment")
category: Between 1st and 2nd dose of CT (Type_of_Biopsy_Prostate#1 "Randomized biopsy")
code: Biopsy (procedure) (snomed.org#86273004)
Entry 19
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation10"
Profile: Observation for Prostate cancer
partOf: See above (Procedure/prostateprocedure02)
status: FINAL
code: Malignant tumor of prostate (disorder) (snomed.org#399068003)
subject: See above (Patient/prostatepatient01)
component
code: Gleason score (observable entity) (snomed.org#372278000)
value: 7
component
code: Histologic grade of urothelial carcinoma by World Health Organization and International Society of Urological Pathology technique (observable entity) (snomed.org#396659000)
value: 4
component
code: |Ratio of number of prostatic tissue cores positive for carcinoma to total number of cores obtained by needle biopsy (observable entity)|:|Relative to (attribute)|=|Structure of right lateral lobe of prostate (body structure)| (snomed.org#372280006:704325000=251597001)
value: 95 % percent (Details: UCUM code % = '%')
component
code: |Ratio of number of prostatic tissue cores positive for carcinoma to total number of cores obtained by needle biopsy (observable entity)|:|Relative to (attribute)|=|Structure of left lateral lobe of prostate (body structure)| (snomed.org#372280006:704325000=251695000)
value: 60 % percent (Details: UCUM code % = '%')
component
code: Non-infiltrating intraductal carcinoma (morphologic abnormality) (snomed.org#86616005)
value: true
component
code: Cribriform neoplasm pattern (finding) (snomed.org#443987001)
value: true
component
code: American Joint Committee on Cancer pT3b (qualifier value) (snomed.org#1229861009)
value: true
component
code: American Joint Committee on Cancer pT3 (qualifier value) (snomed.org#1229859000)
value: true
component
code: Gleason score (observable entity) (snomed.org#372278000)
value: 6
component
code: American Joint Committee on Cancer pathological T category allowable value (qualifier value) (snomed.org#1222589003)
value: pT1 (PT_histology_mutations_Prostate#1)
component
code: American Joint Committee on Cancer pathological N category allowable value (qualifier value) (snomed.org#1222590007)
value: N1 (PN_histology_mutations_Prostate#1)
Entry 20
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation11"
Profile: Observation for Prostate cancer
status: FINAL
code: Malignant tumor of prostate (disorder) (snomed.org#399068003)
subject: See above (Patient/prostatepatient01)
component
code: Sampling - action (qualifier value) (snomed.org#257915005)
value: Light microscopy
component
code: Staining method (procedure) (snomed.org#127790008)
value: Hematoxylin
component
code: Microscopic specimen observation (finding) (snomed.org#395538009)
value: x10
component
code: Biopsy finding (finding) (snomed.org#365855009)
value: example
Entry 21
Request:
POST Observation
Resource Observation:
Generated Narrative: Observation
Resource Observation "prostateobservation12"
Profile: Observation for Prostate cancer
status: FINAL
category: Between 1st and 2nd dose of CT (), Exam label ()
code: After 1st Treatment (Label_Exam#1)
subject: See above (Patient/prostatepatient01)
value: 2
component
code: Leukocytes [#/volume] in Stem cell product (LOINC#95218-4)
value: 15.8 per microlitre (Details: UCUM code x10^9/L = 'x10^9/L')
component
code: Hemoglobin [Mass/volume] in Blood (LOINC#718-7)
value: 16.7 gram per decilitre (Details: UCUM code gr/dL = 'gr/dL')
component
code: Hematocrit [Volume Fraction] of Blood (LOINC#20570-8)
value: 47.4 % percent (Details: UCUM code % = '%')
component
code: Platelets [#/volume] in Blood (LOINC#26515-7)
value: 287 per nanolitre (Details: UCUM code x10^3/μL = 'x10^3/μL')
component
code: Glucose [Mass/volume] in Venous blood (LOINC#41652-9)
value: 87 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
component
code: Insulin [Units/volume] in Serum or Plasma (LOINC#20448-7)
value: 4 milli-international unit per litre (Details: UCUM code mlU/L = 'mlU/L')
component
code: Urea [Mass/volume] in Blood (LOINC#20977-5)
value: 36 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
component
code: Creatinine [Mass/volume] in Blood (LOINC#38483-4)
value: 0.72 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
component
code: Urate [Mass/volume] in Blood (LOINC#98981-4)
value: 3.5 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
component
code: Potassium [Mass/volume] in Blood (LOINC#75940-7)
value: 4.8 millimole per litre (Details: UCUM code mmol/L = 'mmol/L')
component
code: Sodium [Moles/volume] in Blood (LOINC#2947-0)
value: 142 millimole per litre (Details: UCUM code mmol/L = 'mmol/L')
component
code: Calcium [Mass/volume] in Blood (LOINC#49765-1)
value: 9.31 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
component
code: Cholesterol [Mass/volume] in Serum or Plasma (LOINC#2093-3)
value: 197 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
component
code: Triglyceride [Mass/volume] in Blood (LOINC#3043-7)
value: 59 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
component
code: Cholesterol in HDL [Mass/volume] in Serum or Plasma (LOINC#2085-9)
value: 60 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
component
code: Cholesterol in LDL [Mass/volume] in Serum or Plasma (LOINC#2089-1)
value: 120 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
component
code: Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma (LOINC#1920-8)
value: 19 enzyme unit per litre (Details: UCUM code U/L = 'U/L')
component
code: Alanine aminotransferase [Enzymatic activity/volume] in Blood (LOINC#76625-3)
value: 33 enzyme unit per litre (Details: UCUM code U/L = 'U/L')
component
code: Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma (LOINC#2324-2)
value: 14 enzyme unit per litre (Details: UCUM code U/L = 'U/L')
component
code: Alkaline phosphatase [Enzymatic activity/volume] in Blood (LOINC#1783-0)
value: 227 enzyme unit per litre (Details: UCUM code U/L = 'U/L')
component
code: Lactate dehydrogenase [Enzymatic activity/volume] in Red Blood Cells (LOINC#11053-6)
value: 270 enzyme unit per litre (Details: UCUM code U/L = 'U/L')
component
code: Thyrotropin [Units/volume] in Blood (LOINC#3015-5)
value: 0.73 milli-international unit per litre (Details: UCUM code mlU/L = 'mlU/L')
component
code: Cortisol [Mass/volume] in Serum or Plasma (LOINC#2143-6)
value: 22 gram per decilitre (Details: UCUM code g/dL = 'g/dL')
component
code: C reactive protein [Mass/volume] in Blood by High sensitivity method (LOINC#71426-1)
value: 0.5 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
component
code: Natriuretic peptide B [Mass/volume] in Blood (LOINC#42637-9)
value: 120 picogram per millilitre (Details: UCUM code pg/mL = 'pg/mL')
component
code: Hemoglobin A1c/Hemoglobin.total in Blood by HPLC (LOINC#17856-6)
value: 5.1 % percent (Details: UCUM code % = '%')
component
code: Albumin/Protein.total in 24 hour Urine by Electrophoresis (LOINC#13986-5)
value: 80 milligram per 24 hour (Details: UCUM code mg/24h = 'mg/24h')
component
code: Creatinine [Mass/volume] in Urine (LOINC#2161-8)
value: 100 milligram per decilitre (Details: UCUM code mg/dL = 'mg/dL')
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