INCISIVE Implementation Guide
0.1.1 - draft
INCISIVE Implementation Guide
0.1.1 - draft
INCISIVE Implementation Guide - Local Development build (v0.1.1) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions
<Bundle xmlns="http://hl7.org/fhir">
<id value="Colorectal-Cancer-Message-Bundle-Example"/>
<identifier>
<value value="Colorectal Cancer INCISIVE"/>
</identifier>
<type value="transaction"/>
<timestamp value="2023-07-25T12:29:17.239+02:00"/>
<entry>
<resource>
<MessageHeader>
<id value="colorectalmessageheader"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="MessageHeader_colorectalmessageheader"> </a><p><b>Generated Narrative: MessageHeader</b><a name="colorectalmessageheader"> </a><a name="hccolorectalmessageheader"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MessageHeader "colorectalmessageheader" </p></div><p><b>event</b>: Malignant neoplasm of colon and/or rectum (disorder) (Details: http://snomed.org code 781382000 = '781382000', stated as 'Malignant neoplasm of colon and/or rectum (disorder)')</p><h3>Destinations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td><td><b>Endpoint</b></td></tr><tr><td style="display: none">*</td><td>example</td><td><a href="https://exemple.com/services?wsdl">https://exemple.com/services?wsdl</a></td></tr></table><p><b>sender</b>: <a href="#Organization_colorectalorganization01">See above (Organization/colorectalorganization01)</a></p><h3>Sources</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td><td><b>Contact</b></td><td><b>Endpoint</b></td></tr><tr><td style="display: none">*</td><td>example</td><td><a href="mailto:example@example.com">example@example.com</a></td><td><a href="https://exemple.cat/origin">https://exemple.cat/origin</a></td></tr></table><p><b>focus</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p></div>
</text>
<eventCoding>
<system value="http://snomed.org"/>
<code value="781382000"/>
<display
value="Malignant neoplasm of colon and/or rectum (disorder)"/>
</eventCoding>
<destination>
<name value="example"/>
<endpoint value="https://exemple.com/services?wsdl"/>
</destination>
<sender>
<reference value="Organization/colorectalorganization01"/>
<type value="Organization"/>
</sender>
<source>
<name value="example"/>
<contact>
<system value="email"/>
<value value="example@example.com"/>
</contact>
<endpoint value="https://exemple.cat/origin"/>
</source>
<focus>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</focus>
</MessageHeader>
</resource>
<request>
<method value="POST"/>
<url value="MessageHeader"/>
</request>
</entry>
<entry>
<resource>
<Organization>
<id value="colorectalorganization01"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/OrganizationINCISIVE"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_colorectalorganization01"> </a><p><b>Generated Narrative: Organization</b><a name="colorectalorganization01"> </a><a name="hccolorectalorganization01"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization "colorectalorganization01" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-OrganizationINCISIVE.html">Organization for Breast, Colorectal, Lung and Prostate cancer</a></p></div><p><b>identifier</b>: AUTH/?ngen-9?</p><p><b>name</b>: Aristotle university of Thessaloniki</p></div>
</text>
<identifier>
<type>
<coding>
<system
value="https://fhir.incisive-project.eu/CodeSystem/INCISIVEDataProviders"/>
<code value="001"/>
<display value="AUTH"/>
</coding>
</type>
</identifier>
<name value="Aristotle university of Thessaloniki"/>
</Organization>
</resource>
<request>
<method value="POST"/>
<url value="Organization"/>
</request>
</entry>
<entry>
<resource>
<Medication>
<id value="colorectalmedication01"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Medication_colorectalmedication01"> </a><p><b>Generated Narrative: Medication</b><a name="colorectalmedication01"> </a><a name="hccolorectalmedication01"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Medication "colorectalmedication01" </p></div><p><b>code</b>: Medication therapy <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#373873005 "Pharmaceutical / biologic product (product)")</span></p><p><b>status</b>: active</p></div>
</text>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="373873005"/>
<display value="Pharmaceutical / biologic product (product)"/>
</coding>
<text value="Medication therapy"/>
</code>
<status value="active"/>
</Medication>
</resource>
<request>
<method value="POST"/>
<url value="Medication"/>
</request>
</entry>
<entry>
<resource>
<Patient>
<id value="colorectalpatient01"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/PatientINCISIVE"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Patient_colorectalpatient01"> </a><p><b>Generated Narrative: Patient</b><a name="colorectalpatient01"> </a><a name="hccolorectalpatient01"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Patient "colorectalpatient01" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-PatientINCISIVE.html">Patient for Breast, Colorectal, Lung and Prostate cancer</a></p></div><p><b>CurrentState</b>: 0</p><p><b>Ethnicity</b>: White <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ([not stated]#1)</span></p><p><b>identifier</b>: Pseudo-anonimized Identifier/004-000001</p><p><b>gender</b>: female</p><p><b>managingOrganization</b>: <a href="#Organization_colorectalorganization01">See above (Organization/colorectalorganization01)</a></p></div>
</text>
<extension
url="https://fhir.incisive-project.eu/StructureDefinition/CurrentState">
<valueCode value="0"/>
</extension>
<extension
url="https://fhir.incisive-project.eu/StructureDefinition/Ethnicity">
<valueCodeableConcept>
<coding>
<code value="1"/>
<display value="White"/>
</coding>
</valueCodeableConcept>
</extension>
<identifier>
<type>
<text value="Pseudo-anonimized Identifier"/>
</type>
<value value="004-000001"/>
</identifier>
<gender value="female"/>
<managingOrganization>
<reference value="Organization/colorectalorganization01"/>
</managingOrganization>
</Patient>
</resource>
<request>
<method value="POST"/>
<url value="Patient"/>
</request>
</entry>
<entry>
<resource>
<Condition>
<id value="colorectalcondition01"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ConditionForBreastColorectalProstate"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Condition_colorectalcondition01"> </a><p><b>Generated Narrative: Condition</b><a name="colorectalcondition01"> </a><a name="hccolorectalcondition01"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Condition "colorectalcondition01" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ConditionINCISIVE.html">Condition for Breast, Colorectal, Lung and Prostate cancer</a></p></div><p><b>code</b>: N39.8 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOMED CT</a>#417662000 "History of clinical finding in subject (situation)")</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><h3>Evidences</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td>Hereditary non-polyposis colon cancer syndrome (HNPCC) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ColorectalSyndromes.html">Syndromes_Colorectal</a>#2)</span></td></tr></table></div>
</text>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="417662000"/>
<display
value="History of clinical finding in subject (situation)"/>
</coding>
<text value="N39.8"/>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
</subject>
<evidence>
<code>
<coding>
<system
value="https://fhir.incisive-project.eu/CodeSystem/ColorectalSyndromes"/>
<code value="2"/>
<display
value="Hereditary non-polyposis colon cancer syndrome (HNPCC)"/>
</coding>
</code>
</evidence>
</Condition>
</resource>
<request>
<method value="POST"/>
<url value="Condition"/>
</request>
</entry>
<entry>
<resource>
<Observation>
<id value="colorectalobservation01"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ObservationForColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_colorectalobservation01"> </a><p><b>Generated Narrative: Observation</b><a name="colorectalobservation01"> </a><a name="hccolorectalobservation01"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "colorectalobservation01" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ObservationForColorectal.html">Observation for Colorectal cancer</a></p></div><p><b>status</b>: final</p><p><b>code</b>: Malignant neoplasm of colon and/or rectum (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#781382000)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>note</b>: Observation note</p><blockquote><p><b>component</b></p><p><b>code</b>: |Family history of cancer (situation)|:|Subject relationship context (attribute)|=|Father (person)| <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#275937001:408732007=66839005)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: |Family history of cancer (situation)|:|Subject relationship context (attribute)|=|Mother (person)| <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#275937001:408732007=72705000)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Carcinoembryonic Ag [Mass/volume] in Serum or Plasma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#2039-6)</span></p><p><b>value</b>: 11.9 nanogram per millliiter<span style="background: LightGoldenRodYellow"> (Details: UCUM code ng/mL = 'ng/mL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Cancer Ag 19-9 [Units/volume] in Serum or Plasma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#24108-3)</span></p><p><b>value</b>: 37 enzyme unit per millilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code U/mL = 'U/mL')</span></p></blockquote></div>
</text>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="781382000"/>
<display
value="Malignant neoplasm of colon and/or rectum (disorder)"/>
</coding>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</subject>
<note>
<text value="Observation note"/>
</note>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="275937001:408732007=66839005"/>
<display
value="|Family history of cancer (situation)|:|Subject relationship context (attribute)|=|Father (person)|"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="275937001:408732007=72705000"/>
<display
value="|Family history of cancer (situation)|:|Subject relationship context (attribute)|=|Mother (person)|"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="2039-6"/>
<display
value="Carcinoembryonic Ag [Mass/volume] in Serum or Plasma"/>
</coding>
</code>
<valueQuantity>
<value value="11.9"/>
<unit value="nanogram per millliiter"/>
<system value="http://unitsofmeasure.org"/>
<code value="ng/mL"/>
</valueQuantity>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="24108-3"/>
<display
value="Cancer Ag 19-9 [Units/volume] in Serum or Plasma"/>
</coding>
</code>
<valueQuantity>
<value value="37"/>
<unit value="enzyme unit per millilitre"/>
<system value="http://unitsofmeasure.org"/>
<code value="U/mL"/>
</valueQuantity>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<resource>
<DiagnosticReport>
<id value="colorectaldiagnosticReport01"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/DiagnosticReportINCISIVE"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="DiagnosticReport_colorectaldiagnosticReport01"> </a><p><b>Generated Narrative: DiagnosticReport</b><a name="colorectaldiagnosticReport01"> </a><a name="hccolorectaldiagnosticReport01"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DiagnosticReport "colorectaldiagnosticReport01" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-DiagnosticReportINCISIVE.html">DiagnosticReport for Breast, Colorectal, Lung and Prostate cancer</a></p></div><p><b>AgeAtDiagnosis</b>: 56</p><p><b>status</b>: final</p><p><b>code</b>: Malignant neoplasm of colon and/or rectum (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#781382000)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>result</b>: <a href="#Observation_colorectalobservation01">See above (Observation/colorectalobservation01)</a></p></div>
</text>
<extension
url="https://fhir.incisive-project.eu/StructureDefinition/AgeAtDiagnosis">
<valueAge>
<value value="56"/>
</valueAge>
</extension>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="781382000"/>
<display
value="Malignant neoplasm of colon and/or rectum (disorder)"/>
</coding>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
</subject>
<result>
<reference value="Observation/colorectalobservation01"/>
</result>
</DiagnosticReport>
</resource>
<request>
<method value="POST"/>
<url value="DiagnosticReport"/>
</request>
</entry>
<entry>
<resource>
<Observation>
<id value="colorectalobservation02"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ObservationForColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_colorectalobservation02"> </a><p><b>Generated Narrative: Observation</b><a name="colorectalobservation02"> </a><a name="hccolorectalobservation02"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "colorectalobservation02" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ObservationForColorectal.html">Observation for Colorectal cancer</a></p></div><p><b>status</b>: final</p><p><b>code</b>: Malignant neoplasm of colon and/or rectum (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#781382000)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>bodySite</b>: Ovary <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ColorectalDistantMetastasisLocation.html">Distant_metastasis_location_Colorectal</a>#3)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Altered bowel function (finding) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#88111009)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Iron deficiency anemia (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#87522002)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Intestinal obstruction (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#81060008)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Weight loss (finding) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#89362005)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Laboratory procedure performed (situation) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#165331007)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Primary tumor size (observable entity) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#399734001)</span></p><p><b>value</b>: 4.8 centimetre<span style="background: LightGoldenRodYellow"> (Details: UCUM code cm = 'cm')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Structure of lymph node (body structure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#59441001)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Lymph node station of involved lymph nodes (observable entity) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#443097008)</span></p><p><b>value</b>: 13</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Length of lymph node in excised specimen (observable entity) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#364109001)</span></p><p><b>value</b>: 9 centimetre<span style="background: LightGoldenRodYellow"> (Details: UCUM code cm = 'cm')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: pM category (observable entity) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#371497001)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: T category (observable entity) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#78873005)</span></p><p><b>value</b>: Tis</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: N category (observable entity) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#277206009)</span></p><p><b>value</b>: N0</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: M category (observable entity) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#277208005)</span></p><p><b>value</b>: M0</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Tumor stage finding (finding) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#385356007)</span></p><p><b>value</b>: IIA</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Malignant tumor of rectum (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#363351006)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Melanocyte stimulating hormone releasing factor (substance) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#43440003)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Venous (large vessel) extramural invasion by tumor present (finding) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#369734008)</span></p><p><b>value</b>: true</p></blockquote></div>
</text>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="781382000"/>
<display
value="Malignant neoplasm of colon and/or rectum (disorder)"/>
</coding>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</subject>
<bodySite>
<coding>
<system
value="https://fhir.incisive-project.eu/CodeSystem/ColorectalDistantMetastasisLocation"/>
<code value="3"/>
<display value="Ovary"/>
</coding>
</bodySite>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="88111009"/>
<display value="Altered bowel function (finding)"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="87522002"/>
<display value="Iron deficiency anemia (disorder)"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="81060008"/>
<display value="Intestinal obstruction (disorder)"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="89362005"/>
<display value="Weight loss (finding)"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="165331007"/>
<display value="Laboratory procedure performed (situation)"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="399734001"/>
<display value="Primary tumor size (observable entity)"/>
</coding>
</code>
<valueQuantity>
<value value="4.8"/>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Condition_colorectalcondition03"> </a><p><b>Generated Narrative: Condition</b><a name="colorectalcondition03"> </a><a name="hccolorectalcondition03"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Condition "colorectalcondition03" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ConditionINCISIVE.html">Condition for Breast, Colorectal, Lung and Prostate cancer</a></p></div><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><h3>Evidences</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td>Other symptoms <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#404684003 "Clinical finding (finding)")</span></td></tr></table></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="MedicationAdministration_colorectalmedicationAdministration01"> </a><p><b>Generated Narrative: MedicationAdministration</b><a name="colorectalmedicationAdministration01"> </a><a name="hccolorectalmedicationAdministration01"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MedicationAdministration "colorectalmedicationAdministration01" </p></div><p><b>status</b>: completed</p><p><b>medication</b>: <a href="#Medication_colorectalmedication01">See above (Medication/colorectalmedication01)</a></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>effective</b>: 2023-07-25 17:07:54+0000</p><h3>Dosages</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Route</b></td><td><b>Dose</b></td></tr><tr><td style="display: none">*</td><td>|Delivered radiation dose (observable entity)|:|Direct site (attribute)|=|Breast structure (body structure)|, |Units (attribute)|=|Gray (qualifier value)| <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#371892002:704327008=76752008, 246514001=229029004)</span></td><td>40.4</td></tr></table></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="MedicationAdministration_colorectalmedicationAdministration02"> </a><p><b>Generated Narrative: MedicationAdministration</b><a name="colorectalmedicationAdministration02"> </a><a name="hccolorectalmedicationAdministration02"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MedicationAdministration "colorectalmedicationAdministration02" </p></div><p><b>status</b>: completed</p><p><b>medication</b>: <a href="#Medication_colorectalmedication01">See above (Medication/colorectalmedication01)</a></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>effective</b>: 2023-07-25 17:07:54+0000</p><h3>Dosages</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Route</b></td><td><b>Dose</b></td><td><b>Rate[x]</b></td></tr><tr><td style="display: none">*</td><td>|Delivered radiation dose (observable entity)|:|Direct site (attribute)|=|Structure of lymph node (body structure)|, |Units (attribute)|=|Gray (qualifier value)| <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#371892002:704327008=59441001, 246514001=229029004)</span></td><td>50.4</td><td>28 fractions</td></tr></table></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_colorectalobservation05"> </a><p><b>Generated Narrative: Observation</b><a name="colorectalobservation05"> </a><a name="hccolorectalobservation05"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "colorectalobservation05" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ObservationForColorectal.html">Observation for Colorectal cancer</a></p></div><p><b>partOf</b>: </p><ul><li><a href="#MedicationAdministration_colorectalmedicationAdministration01">See above (MedicationAdministration/colorectalmedicationAdministration01)</a></li><li><a href="#MedicationAdministration_colorectalmedicationAdministration02">See above (MedicationAdministration/colorectalmedicationAdministration02)</a></li></ul><p><b>status</b>: final</p><p><b>category</b>: Between 1st and 2nd dose of CT <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span>, Label treatment <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>code</b>: After 1st Treatment-1st FollowUp <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-LabelTreatment.html">Label_Treatment</a>#1)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>|Administration of drug or medicament (procedure)|:|Has intent (attribute)|=|Neo-adjuvant - intent (qualifier value)| <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#18629005:363703001=373847000)</span></td><td>true</td></tr></table></div>
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<system value="http://snomed.org"/>
<code value="387713003:370130000=410656007"/>
<display
value="|Surgical procedure (procedure)|:|Property (attribute)|=|Type (property) (qualifier value)|"/>
</coding>
<text value="Segmentomy"/>
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<code>
<coding>
<system value="http://snomed.org"/>
<code value="387713003"/>
<display value="Surgical procedure (procedure)"/>
</coding>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
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<performedString value="2"/>
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<request>
<method value="POST"/>
<url value="Procedure"/>
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</entry>
<entry>
<resource>
<Procedure>
<id value="colorectalprocedure02"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ProcedureForLungAndColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_colorectalprocedure02"> </a><p><b>Generated Narrative: Procedure</b><a name="colorectalprocedure02"> </a><a name="hccolorectalprocedure02"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Procedure "colorectalprocedure02" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ProcedureForLungAndColorectal.html">Procedure for Lung and Colorectal cancer</a></p></div><p><b>status</b>: completed</p><p><b>code</b>: Capecitabine <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#367336001:370130000=410656007 "|Chemotherapy (procedure)|:|Property (attribute)|=|Type (property) (qualifier value)|")</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>performed</b>: 2</p></div>
</text>
<status value="completed"/>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="367336001:370130000=410656007"/>
<display
value="|Chemotherapy (procedure)|:|Property (attribute)|=|Type (property) (qualifier value)|"/>
</coding>
<text value="Capecitabine"/>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
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<performedString value="2"/>
</Procedure>
</resource>
<request>
<method value="POST"/>
<url value="Procedure"/>
</request>
</entry>
<entry>
<resource>
<Procedure>
<id value="colorectalprocedure03"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ProcedureForLungAndColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_colorectalprocedure03"> </a><p><b>Generated Narrative: Procedure</b><a name="colorectalprocedure03"> </a><a name="hccolorectalprocedure03"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Procedure "colorectalprocedure03" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ProcedureForLungAndColorectal.html">Procedure for Lung and Colorectal cancer</a></p></div><p><b>status</b>: completed</p><p><b>code</b>: Nitrosoureas <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#703423002:370130000=410656007 "|Combined chemotherapy and radiation therapy (procedure)|:|Property (attribute)|=|Type (property) (qualifier value)|")</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>performed</b>: 2</p></div>
</text>
<status value="completed"/>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="703423002:370130000=410656007"/>
<display
value="|Combined chemotherapy and radiation therapy (procedure)|:|Property (attribute)|=|Type (property) (qualifier value)|"/>
</coding>
<text value="Nitrosoureas"/>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</subject>
<performedString value="2"/>
</Procedure>
</resource>
<request>
<method value="POST"/>
<url value="Procedure"/>
</request>
</entry>
<entry>
<resource>
<Procedure>
<id value="colorectalprocedure04"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ProcedureForLungAndColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_colorectalprocedure04"> </a><p><b>Generated Narrative: Procedure</b><a name="colorectalprocedure04"> </a><a name="hccolorectalprocedure04"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Procedure "colorectalprocedure04" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ProcedureForLungAndColorectal.html">Procedure for Lung and Colorectal cancer</a></p></div><p><b>status</b>: completed</p><p><b>code</b>: Tamoxifen <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#897713009:370130000=410656007 "|Antineoplastic chemoimmunotherapy (regime/therapy)|:|Property (attribute)|=|Type (property) (qualifier value)|")</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>performed</b>: 2</p></div>
</text>
<status value="completed"/>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="897713009:370130000=410656007"/>
<display
value="|Antineoplastic chemoimmunotherapy (regime/therapy)|:|Property (attribute)|=|Type (property) (qualifier value)|"/>
</coding>
<text value="Tamoxifen"/>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</subject>
<performedString value="2"/>
</Procedure>
</resource>
<request>
<method value="POST"/>
<url value="Procedure"/>
</request>
</entry>
<entry>
<resource>
<Procedure>
<id value="colorectalprocedure05"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ProcedureForLungAndColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_colorectalprocedure05"> </a><p><b>Generated Narrative: Procedure</b><a name="colorectalprocedure05"> </a><a name="hccolorectalprocedure05"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Procedure "colorectalprocedure05" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ProcedureForLungAndColorectal.html">Procedure for Lung and Colorectal cancer</a></p></div><p><b>status</b>: completed</p><p><b>code</b>: Radiation therapy care (regime/therapy) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#385798007)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>performed</b>: 2</p><p><b>bodySite</b>: Rectum <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ColorectalLocationOfRT.html">Location_of_RT_Colorectal</a>#1)</span></p></div>
</text>
<status value="completed"/>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="385798007"/>
<display value="Radiation therapy care (regime/therapy)"/>
</coding>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</subject>
<performedString value="2"/>
<bodySite>
<coding>
<system
value="https://fhir.incisive-project.eu/CodeSystem/ColorectalLocationOfRT"/>
<code value="1"/>
<display value="Rectum"/>
</coding>
</bodySite>
</Procedure>
</resource>
<request>
<method value="POST"/>
<url value="Procedure"/>
</request>
</entry>
<entry>
<resource>
<Procedure>
<id value="colorectalprocedure06"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ProcedureForLungAndColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_colorectalprocedure06"> </a><p><b>Generated Narrative: Procedure</b><a name="colorectalprocedure06"> </a><a name="hccolorectalprocedure06"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Procedure "colorectalprocedure06" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ProcedureForLungAndColorectal.html">Procedure for Lung and Colorectal cancer</a></p></div><p><b>status</b>: completed</p><p><b>category</b>: Segmentomy <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#387713003 "Surgical procedure (procedure)")</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>performed</b>: 2</p></div>
</text>
<status value="completed"/>
<category>
<coding>
<system value="http://snomed.org"/>
<code value="387713003"/>
<display value="Surgical procedure (procedure)"/>
</coding>
<text value="Segmentomy"/>
</category>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</subject>
<performedString value="2"/>
</Procedure>
</resource>
<request>
<method value="POST"/>
<url value="Procedure"/>
</request>
</entry>
<entry>
<resource>
<Observation>
<id value="colorectalobservation06"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ObservationForColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_colorectalobservation06"> </a><p><b>Generated Narrative: Observation</b><a name="colorectalobservation06"> </a><a name="hccolorectalobservation06"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "colorectalobservation06" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ObservationForColorectal.html">Observation for Colorectal cancer</a></p></div><p><b>status</b>: final</p><p><b>code</b>: Malignant neoplasm of colon and/or rectum (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#781382000)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: KRAS gene mutations tested for in Blood or Tissue by Molecular genetics method Nominal <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#21703-4)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: GSTP1 gene+APC gene methylation [Presence] in Tissue by Molecular genetics method <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#59585-0)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: TP53 gene mutations found [Identifier] in Blood or Tissue by Molecular genetics method Nominal <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#21739-8)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 18q chromosome deletion [Identifier] in Blood or Tissue by Molecular genetics method Nominal <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#46108-7)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: TGFBR1 gene+TGFBR2 gene targeted mutation analysis in Blood or Tissue by Molecular genetics method <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#53899-1)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: PIK3CA gene [VCF] in Cancer specimen by Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#83062-0)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Microsatellite markers exhibiting instability/Microsatellite instability markers assessed in Cancer specimen <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#81708-0)</span></p><p><b>value</b>: true</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: DNA mismatch repair protein Msh3 [Presence] in Cancer specimen by Immune stain <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#96271-2)</span></p><p><b>value</b>: true</p></blockquote></div>
</text>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="781382000"/>
<display
value="Malignant neoplasm of colon and/or rectum (disorder)"/>
</coding>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</subject>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="21703-4"/>
<display
value="KRAS gene mutations tested for in Blood or Tissue by Molecular genetics method Nominal"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="59585-0"/>
<display
value="GSTP1 gene+APC gene methylation [Presence] in Tissue by Molecular genetics method"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="21739-8"/>
<display
value="TP53 gene mutations found [Identifier] in Blood or Tissue by Molecular genetics method Nominal"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="46108-7"/>
<display
value="18q chromosome deletion [Identifier] in Blood or Tissue by Molecular genetics method Nominal"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="53899-1"/>
<display
value="TGFBR1 gene+TGFBR2 gene targeted mutation analysis in Blood or Tissue by Molecular genetics method"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="83062-0"/>
<display
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</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="81708-0"/>
<display
value="Microsatellite markers exhibiting instability/Microsatellite instability markers assessed in Cancer specimen"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="96271-2"/>
<display
value="DNA mismatch repair protein Msh3 [Presence] in Cancer specimen by Immune stain"/>
</coding>
</code>
<valueBoolean value="true"/>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<resource>
<Observation>
<id value="colorectalobservation07"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ObservationForColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_colorectalobservation07"> </a><p><b>Generated Narrative: Observation</b><a name="colorectalobservation07"> </a><a name="hccolorectalobservation07"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "colorectalobservation07" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ObservationForColorectal.html">Observation for Colorectal cancer</a></p></div><p><b>status</b>: final</p><p><b>code</b>: Malignant neoplasm of colon and/or rectum (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#781382000)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Sampling - action (qualifier value) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#257915005)</span></p><p><b>value</b>: Light microscopy</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Staining method (procedure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#127790008)</span></p><p><b>value</b>: Hematoxylin</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Microscopic specimen observation (finding) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#395538009)</span></p><p><b>value</b>: x10</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Biopsy finding (finding) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#365855009)</span></p><p><b>value</b>: example</p></blockquote></div>
</text>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="781382000"/>
<display
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</coding>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</subject>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="257915005"/>
<display value="Sampling - action (qualifier value)"/>
</coding>
</code>
<valueString value="Light microscopy"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="127790008"/>
<display value="Staining method (procedure)"/>
</coding>
</code>
<valueString value="Hematoxylin"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="395538009"/>
<display value="Microscopic specimen observation (finding)"/>
</coding>
</code>
<valueString value="x10"/>
</component>
<component>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="365855009"/>
<display value="Biopsy finding (finding)"/>
</coding>
</code>
<valueString value="example"/>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<resource>
<Procedure>
<id value="colorectalprocedure07"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ProcedureForLungAndColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_colorectalprocedure07"> </a><p><b>Generated Narrative: Procedure</b><a name="colorectalprocedure07"> </a><a name="hccolorectalprocedure07"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Procedure "colorectalprocedure07" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ProcedureForLungAndColorectal.html">Procedure for Lung and Colorectal cancer</a></p></div><p><b>status</b>: completed</p><p><b>statusReason</b>: Biopsy label <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-LabelBiopsy.html">Label_Biopsy</a>#1 "After 1st Treatment")</span></p><p><b>category</b>: Between 1st and 2nd dose of CT <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>code</b>: Biopsy (procedure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#86273004)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>performed</b>: 2</p></div>
</text>
<status value="completed"/>
<statusReason>
<coding>
<system
value="https://fhir.incisive-project.eu/CodeSystem/LabelBiopsy"/>
<code value="1"/>
<display value="After 1st Treatment"/>
</coding>
<text value="Biopsy label"/>
</statusReason>
<category>
<text value="Between 1st and 2nd dose of CT"/>
</category>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="86273004"/>
<display value="Biopsy (procedure)"/>
</coding>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</subject>
<performedString value="2"/>
</Procedure>
</resource>
<request>
<method value="POST"/>
<url value="Procedure"/>
</request>
</entry>
<entry>
<resource>
<Procedure>
<id value="colorectalprocedure08"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ProcedureForLungAndColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_colorectalprocedure08"> </a><p><b>Generated Narrative: Procedure</b><a name="colorectalprocedure08"> </a><a name="hccolorectalprocedure08"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Procedure "colorectalprocedure08" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ProcedureForLungAndColorectal.html">Procedure for Lung and Colorectal cancer</a></p></div><p><b>status</b>: completed</p><p><b>code</b>: Surgical procedure (procedure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#387713003)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>performed</b>: 2</p></div>
</text>
<status value="completed"/>
<code>
<coding>
<system value="http://snomed.org"/>
<code value="387713003"/>
<display value="Surgical procedure (procedure)"/>
</coding>
</code>
<subject>
<reference value="Patient/colorectalpatient01"/>
<type value="Patient"/>
</subject>
<performedString value="2"/>
</Procedure>
</resource>
<request>
<method value="POST"/>
<url value="Procedure"/>
</request>
</entry>
<entry>
<resource>
<Observation>
<id value="colorectalobservation08"/>
<meta>
<profile
value="https://fhir.incisive-project.eu/StructureDefinition/ObservationForColorectal"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_colorectalobservation08"> </a><p><b>Generated Narrative: Observation</b><a name="colorectalobservation08"> </a><a name="hccolorectalobservation08"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "colorectalobservation08" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ObservationForColorectal.html">Observation for Colorectal cancer</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Adenocarcinoma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ColorectalCancerType.html">Colorectal_Cancer_Type</a>#1)</span></p><p><b>code</b>: Malignant neoplasm of colon (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#363406005)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>|Malignant neoplasm of colon (disorder)|:|Interprets (attribute)|=|Edition of American Joint Commission on Cancer, Cancer Staging Manual used for TNM staging (observable entity)| <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (snomed.org#363406005:363714003=443941007)</span></td><td>1</td></tr></table></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_colorectalobservation09"> </a><p><b>Generated Narrative: Observation</b><a name="colorectalobservation09"> </a><a name="hccolorectalobservation09"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "colorectalobservation09" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ObservationForColorectal.html">Observation for Colorectal cancer</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Between 1st and 2nd dose of CT <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span>, Exam label <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>code</b>: After 1st Treatment <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-LabelExam.html">Label_Exam</a>#1)</span></p><p><b>subject</b>: <a href="#Patient_colorectalpatient01">See above (Patient/colorectalpatient01)</a></p><p><b>value</b>: 2</p><blockquote><p><b>component</b></p><p><b>code</b>: Leukocytes [#/volume] in Stem cell product <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#95218-4)</span></p><p><b>value</b>: 15.8 per microlitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code x10^9/L = 'x10^9/L')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Hemoglobin [Mass/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#718-7)</span></p><p><b>value</b>: 16.7 gram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code gr/dL = 'gr/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Hematocrit [Volume Fraction] of Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#20570-8)</span></p><p><b>value</b>: 47.4 % percent<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Platelets [#/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#26515-7)</span></p><p><b>value</b>: 287 per nanolitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code x10^3/μL = 'x10^3/μL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Glucose [Mass/volume] in Venous blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#41652-9)</span></p><p><b>value</b>: 87 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Insulin [Units/volume] in Serum or Plasma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#20448-7)</span></p><p><b>value</b>: 4 milli-international unit per litre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mlU/L = 'mlU/L')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Urea [Mass/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#20977-5)</span></p><p><b>value</b>: 36 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Creatinine [Mass/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#38483-4)</span></p><p><b>value</b>: 0.72 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Urate [Mass/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#98981-4)</span></p><p><b>value</b>: 3.5 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Potassium [Mass/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#75940-7)</span></p><p><b>value</b>: 4.8 millimole per litre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mmol/L = 'mmol/L')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Sodium [Moles/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#2947-0)</span></p><p><b>value</b>: 142 millimole per litre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mmol/L = 'mmol/L')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Calcium [Mass/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#49765-1)</span></p><p><b>value</b>: 9.31 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Cholesterol [Mass/volume] in Serum or Plasma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#2093-3)</span></p><p><b>value</b>: 197 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Triglyceride [Mass/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#3043-7)</span></p><p><b>value</b>: 59 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Cholesterol in HDL [Mass/volume] in Serum or Plasma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#2085-9)</span></p><p><b>value</b>: 60 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Cholesterol in LDL [Mass/volume] in Serum or Plasma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#2089-1)</span></p><p><b>value</b>: 120 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#1920-8)</span></p><p><b>value</b>: 19 enzyme unit per litre<span style="background: LightGoldenRodYellow"> (Details: UCUM code U/L = 'U/L')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Alanine aminotransferase [Enzymatic activity/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#76625-3)</span></p><p><b>value</b>: 33 enzyme unit per litre<span style="background: LightGoldenRodYellow"> (Details: UCUM code U/L = 'U/L')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#2324-2)</span></p><p><b>value</b>: 14 enzyme unit per litre<span style="background: LightGoldenRodYellow"> (Details: UCUM code U/L = 'U/L')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Alkaline phosphatase [Enzymatic activity/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#1783-0)</span></p><p><b>value</b>: 227 enzyme unit per litre<span style="background: LightGoldenRodYellow"> (Details: UCUM code U/L = 'U/L')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Lactate dehydrogenase [Enzymatic activity/volume] in Red Blood Cells <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#11053-6)</span></p><p><b>value</b>: 270 enzyme unit per litre<span style="background: LightGoldenRodYellow"> (Details: UCUM code U/L = 'U/L')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Thyrotropin [Units/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#3015-5)</span></p><p><b>value</b>: 0.73 milli-international unit per litre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mlU/L = 'mlU/L')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Cortisol [Mass/volume] in Serum or Plasma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#2143-6)</span></p><p><b>value</b>: 22 gram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code g/dL = 'g/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: C reactive protein [Mass/volume] in Blood by High sensitivity method <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#71426-1)</span></p><p><b>value</b>: 0.5 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Natriuretic peptide B [Mass/volume] in Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#42637-9)</span></p><p><b>value</b>: 120 picogram per millilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code pg/mL = 'pg/mL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Hemoglobin A1c/Hemoglobin.total in Blood by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#17856-6)</span></p><p><b>value</b>: 5.1 % percent<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Albumin/Protein.total in 24 hour Urine by Electrophoresis <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#13986-5)</span></p><p><b>value</b>: 80 milligram per 24 hour<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/24h = 'mg/24h')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Creatinine [Mass/volume] in Urine <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#2161-8)</span></p><p><b>value</b>: 100 milligram per decilitre<span style="background: LightGoldenRodYellow"> (Details: UCUM code mg/dL = 'mg/dL')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Carcinoembryonic Ag [Mass/volume] in Serum or Plasma <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#2039-6)</span></p><p><b>value</b>: 11.9 nanogram per millliiter<span style="background: LightGoldenRodYellow"> (Details: UCUM code ng/mL = 'ng/mL')</span></p></blockquote></div>
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